Published in Scientific Papers. Series B, Horticulture, Vol. LXVIV, Issue 1
Written by Marilena-Gabriela OLTEANU ZAHARIE, Nicoleta RADU, Narcisa Elena BĂBEANU, Marinela BOSTAN, Viviana ROMAN
Cytotoxicity studies performed on HUVEC and CaCo-2 cell lines with a polysaccharides-based bioproduct isolated from Plantago lanceolata as well with inulin (for comparison) revealed moderate cytotoxicity after 24-hour exposure to inulin and polysaccharides from Plantago lanceolata. Inulin showed a high selectivity index (SI = 11) for the CaCo-2 tumour cell line, indicating specificity for this cell line. After 48 hours, the polysaccharides from Plantago lanceolata showed no cytotoxicity on either studied cell line. Inulin showed no cytotoxicity to HUVEC cells but exhibited cytotoxicity to CaCo-2 cells, giving a higher selectivity index (SI = 25.3) after 48 hours of exposure. Overall, the polysaccharides from Plantago lanceolata showed similar physicochemical properties to inulin, without cytotoxicity on HUVEC cells and moderate cytotoxicity on CaCo-2 cells after 48 hours of exposure.
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